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CD80 Antibody (OAEC04503)

100 ug/100 ul
$229.00
In Stock
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Predicted Species Reactivity:
Human
Product Format:
Ascitic fluid containing 0.03% sodium azide
Clonality:
Monoclonal
Clone:
2A2
Isotype:
IgG1
Host:
Mouse
Application:
IF, IHC
Reconstitution and Storage:
Store at 4C, for long term storage, store at -20C.
Gene Symbol:
CD80
NCBI Gene Id:
941
Official Gene Full Name:
CD80 molecule
Swissprot Id:
P33681
Alias Symbols:
B7, BB1, B7-1, B7.1, LAB7, CD28LG, CD28LG1,
Replacement Item:
This antibody may replace item sc-115617 from Santa Cruz Biotechnology.
Description of Target:
The protein CD80 (Cluster of Differentiation 80) is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival. It is also known as B7.1. Its principal mode of action is by binding to CD28. Along with CD86, these molecules provide the necessary stimuli to prime T cells against antigens presented by antigen-presenting cells. CD80 and CD86 also bind to CTLA-4, a cell surface molecule expressed on activated T cells. Interactions between CD80 or CD86 with CTLA-4 decrease the response of T cells. Mouse research by scientists at Emory University showed that estrogen-related bone loss is linked to recently discovered pathways involving various proteins, such as CD80 and other functions. In a nutshell, reactive oxygen stimulates dendritic cells, which activate other immune cells to up-regulate production of CD80, the molecule co-responsible for T cell activation. "When this pathway is activated, it leads to increased T cell TNF production and ultimately to bone loss." In turn, T cells produce a protein, Tumor Necrosis Factor, which increases the formation of osteoclasts in rodents and humans.
Molecular Weight:
55 kDa
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CD80.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CD80.
Immunogen:
Purified recombinant fragment of CD80 expres sed in EColi.
Concentration:
1 mg/ml
Datasheets/Manuals:
Printable datasheet for anti-CD80 (OAEC04503) antibody
Application Info:
IHC: 1/200 - 1/1000
IF: 1/200 - 1/1000
ELISA: 1/10000
Figure 1 Immunohistochemical analysis of paraffin-embedded human Tonsil tissues usinganti-CD80 mAb

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