Size:100 ug/100 ul
$229.00
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SKU
OAEC04503
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CD80 Antibody (OAEC04503)

Catalog#: OAEC04503
Domestic: within 1-2 weeks delivery | International: 1-2 weeks
More Information
Predicted Species Reactivity Human
Product Format Ascitic fluid containing 0.03% sodium azide
Clonality Monoclonal
Clone 2A2
Isotype IgG1
Host Mouse
Application IF, IHC
Reconstitution and Storage Store at 4C, for long term storage, store at -20C.
Replacement Item This antibody may replace item sc-115617 from Santa Cruz Biotechnology.
Immunogen Purified recombinant fragment of CD80 expres sed in EColi.
Concentration 1 mg/ml
Datasheets/Manuals Printable datasheet for anti-CD80 (OAEC04503) antibody
Application Info IHC: 1/200 - 1/1000
IF: 1/200 - 1/1000
ELISA: 1/10000
Figure 1 Immunohistochemical analysis of paraffin-embedded human Tonsil tissues usinganti-CD80 mAb
Gene Symbol CD80
Official Gene Full Name CD80 molecule
Alias Symbols B7, BB1, B7-1, B7.1, LAB7, CD28LG, CD28LG1,
NCBI Gene Id 941
Description of Target The protein CD80 (Cluster of Differentiation 80) is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival. It is also known as B7.1. Its principal mode of action is by binding to CD28. Along with CD86, these molecules provide the necessary stimuli to prime T cells against antigens presented by antigen-presenting cells. CD80 and CD86 also bind to CTLA-4, a cell surface molecule expressed on activated T cells. Interactions between CD80 or CD86 with CTLA-4 decrease the response of T cells. Mouse research by scientists at Emory University showed that estrogen-related bone loss is linked to recently discovered pathways involving various proteins, such as CD80 and other functions. In a nutshell, reactive oxygen stimulates dendritic cells, which activate other immune cells to up-regulate production of CD80, the molecule co-responsible for T cell activation. "When this pathway is activated, it leads to increased T cell TNF production and ultimately to bone loss." In turn, T cells produce a protein, Tumor Necrosis Factor, which increases the formation of osteoclasts in rodents and humans.
Swissprot Id P33681
Molecular Weight 55 kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express CD80.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express CD80.
  1. What is the species homology for "CD80 Antibody (OAEC04503)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "CD80 Antibody (OAEC04503)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".

  3. What buffer format is "CD80 Antibody (OAEC04503)" provided in?

    This item is provided in "Ascitic fluid containing 0.03% sodium azide".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "CD80 Antibody (OAEC04503)"?

    This target may also be called "B7, BB1, B7-1, B7.1, LAB7, CD28LG, CD28LG1," in publications.

  5. What is the shipping cost for "CD80 Antibody (OAEC04503)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "CD80 Antibody (OAEC04503)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "CD80 Antibody (OAEC04503)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "55 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "CD80 Antibody (OAEC04503)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "CD80"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "CD80"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "CD80"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "CD80"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "CD80"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "CD80"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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