CD3E Antibody (OABF00425)

Catalog No: OABF00425

Size:100UL

Product Info

• Predicted Species Reactivity: Human|Mouse|Porcine
• Product Format: Liquid Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Flow cytometry|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin
• Additional Information: Subcellular location: Extracellular
• Reconstitution and Storage: -20°C
• Immunogen: KLH conjugated synthetic peptide derived from pig CD3E
• Purification: Protein A Purified
• Concentration: 1 ug/ul
• Application Info: IHC-P: 1:100~500
  Fluorescent-IHC: 1:50~200

Target Info

• Gene Symbol: CD3E
• Gene Full Name: CD3e molecule
• Alias Symbols: CD3;CD3 epsilon subunit;T-cell surface glycoprotein CD3 epsilon chain.
• NCBI Gene Id: 397455
• Protein Name: T-cell surface glycoprotein CD3 epsilon chain
• Description of Target: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.
• Uniprot ID: Q7YRN2