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CBFB Antibody (OADC00013)

100ul
$319.00
In Stock
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Predicted Species Reactivity:
Human
Product Format:
Liquid. Whole antiserum from rabbit containing 0.05% azide.
Clonality:
Polyclonal
Host:
Rabbit
Conjugation:
Unconjugated
Application:
CHIP
Reconstitution and Storage:
Store at -20C. Avoid repeated freeze/thaw cycles.
Replacement Item:
This antibody may replace item sc-122480 from Santa Cruz Biotechnology.
Purification:
Whole antiserum
Concentration:
Undetermined, ascites
Datasheets/Manuals:
Printable datasheet for anti-CBFB (OADC00013) antibody
Preservative:
0.05% Sodium Azide
Specificity:
Polyclonal antibody raised in rabbit against human CBFb (core-binding factor, beta subunit) using two KLH-conjugated synthetic peptides containing sequences from the central region of the protein.
Application Info:
CHIP: 4 ul/CHIP
ELISA: 1:500
Gene Symbol:
CBFB
Official Gene Full Name:
core-binding factor, beta subunit
Alias Symbols:
PEBP2B
NCBI Gene Id:
865;
Protein Name:
core-binding factor subunit beta
Description of Target:
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene.
Swissprot Id:
Q13951
Protein Accession #:
NP_001746.1
Nucleotide Accession #:
NM_001755.2
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CBFB.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CBFB.

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