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ALDOA Antibody - N-terminal region (ARP48130_T100)

100 ul
$229.00
In Stock
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Conjugation Options

ARP48130_T100-FITC Conjugated

ARP48130_T100-HRP Conjugated

ARP48130_T100-Biotin Conjugated

Tested Species Reactivity:
Human
Predicted Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality:
Polyclonal
Host:
Rabbit
Application:
WB
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
ALDOA
Official Gene Full Name:
Aldolase A, fructose-bisphosphate
NCBI Gene Id:
226
Protein Name:
Fructose-bisphosphate aldolase A
Swissprot Id:
P04075
Protein Accession #:
NP_000025
Nucleotide Accession #:
NM_000034
Alias Symbols:
ALDA, MGC10942, MGC17716, MGC17767, GSD12
Replacement Item:
This antibody may replace item sc-112196 from Santa Cruz Biotechnology.
Description of Target:
ALDOA is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia.This gene product, Aldolase A (fructose-bisphosphate aldolase) is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants which encode the same protein.
Protein Size (# AA):
364
Molecular Weight:
39kDa
Purification:
Protein A purified
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express ALDOA.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express ALDOA.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human ALDOA
Predicted Homology Based on Immunogen Sequence:
Cow: 93%; Dog: 100%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 92%; Rabbit: 100%; Rat: 93%; Sheep: 82%; Zebrafish: 92%
Complete computational species homology data:
Anti-ALDOA (ARP48130_T100)
Peptide Sequence:
Synthetic peptide located within the following region: MPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTE
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
HUWE1; UBC; IFNA4; FUS; ALDOC; ALDOA; SUMO2; SUMO3; MDM2; ADRB2; SUZ12; TNPO3; CS; RAD52; VCPKMT; PIAS4; GALNT6; IQCB1; VCAM1; MLH1; ITGA4; HSP90AB1; HSP90AA1; FN1; ATF2; BCAT2; ALDOB; LIG4; PGK1; LGALS1; HSPD1; AKT1; MYOC; CDK2; CUL2; CUL3; CUL4B; ISG15;
Blocking Peptide:
For anti-ALDOA (ARP48130_T100) antibody is Catalog # AAP48130 (Previous Catalog # AAPP28647)
Datasheets/Manuals:
Printable datasheet for anti-ALDOA (ARP48130_T100) antibody
Target Reference:
Lu,J., (2008) Biochem. Biophys. Res. Commun. 369 (3), 948-952
Publications:

Braceland, M. et al. Serum enolase: a non-destructive biomarker of white skeletal myopathy during pancreas disease (PD) in Atlantic salmon Salmo salar L. J. Fish Dis. 38, 821-31 (2015). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish 25168106

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