| Product Number |
ARP48130_T100 |
| Product Page |
www.avivasysbio.com/aldoa-antibody-n-terminal-region-arp48130-t100.html |
| Name |
ALDOA Antibody - N-terminal region (ARP48130_T100) |
| Protein Size (# AA) |
364 amino acids |
| Molecular Weight |
39 kDa |
| NCBI Gene Id |
226 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Aldolase A, fructose-bisphosphate |
| Description |
|
| Alias Symbols |
ALDA, GSD12, HEL-S-87p |
| Peptide Sequence |
Synthetic peptide located within the following region: MPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTE |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Lu,J., (2008) Biochem. Biophys. Res. Commun. 369 (3), 948-952 |
| Description of Target |
ALDOA is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia.This gene product, Aldolase A (fructose-bisphosphate aldolase) is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants which encode the same protein. |
| Protein Interactions |
HUWE1; UBC; IFNA4; FUS; ALDOC; ALDOA; SUMO2; SUMO3; MDM2; ADRB2; SUZ12; TNPO3; CS; RAD52; VCPKMT; PIAS4; GALNT6; IQCB1; VCAM1; MLH1; ITGA4; HSP90AB1; HSP90AA1; FN1; ATF2; BCAT2; ALDOB; LIG4; PGK1; LGALS1; HSPD1; AKT1; MYOC; CDK2; CUL2; CUL3; CUL4B; ISG15; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-ALDOA (ARP48130_T100) antibody |
| Blocking Peptide |
For anti-ALDOA (ARP48130_T100) antibody is Catalog # AAP48130 (Previous Catalog # AAPP28647) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human ALDOA |
| Uniprot ID |
P04075 |
| Protein Name |
Fructose-bisphosphate aldolase A |
| Publications |
Braceland, M. et al. Serum enolase: a non-destructive biomarker of white skeletal myopathy during pancreas disease (PD) in Atlantic salmon Salmo salar L. J. Fish Dis. doi:10.1111/jfd.12296 (2014). 25168106
Chaperone-Mediated Autophagy in the Light of Evolution: Insight from Fish. Mol Biol Evol. 37, 2887-2899 (2020) 32437540 |
| Protein Accession # |
NP_000025 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_000034 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
ALDOA |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 93%; Dog: 100%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 92%; Rabbit: 100%; Rat: 93%; Sheep: 82%; Zebrafish: 92% |
| Image 1 |
 | 25 ug of the indicated Human whole cell extracts was loaded onto a 12% SDS-PAGE gel. 1 ug/mL of the antibody was used in this experiment.
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