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- Email: info@avivasysbio.com
- $55: Antibody & Protein in US
- $55 + $25/Kit in US
- Contact us for international orders.
| Datasheets/Manuals | Printable datasheet for TGFB1 Antibody (OACD00156) |
|---|
| Predicted Species Reactivity | Human|Mouse|Rat |
|---|---|
| Product Format | Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Clonality | Monoclonal |
| Clone | C1 |
| Isotype | IgG2a Kappa |
| Host | Mouse |
| Application | Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot |
| Reconstitution and Storage | 2°C to 8°C|-20°C |
| Immunogen | Recombinant TGFb1 (Ala279~Ser390) expressed in E.coli. |
| Purification | Protein A/G Purified |
| Concentration | 0.97 mg/ml |
| Application Info | WB: 0.5-5 ug/mL IHC: 5-20 ug/mL ICC: 5-20 ug/mL |
| Gene Symbol | TGFB1 |
|---|---|
| Gene Full Name | transforming growth factor beta 1 |
| Alias Symbols | CED;DPD1;IBDIMDE;LAP;latency-associated peptide;prepro-transforming growth factor beta-1;TGFB;TGFbeta;TGF-beta1;TGF-beta-1;transforming growth factor beta1;transforming growth factor beta-1 proprotein. |
| NCBI Gene Id | 7040 |
| Protein Name | Transforming growth factor beta-1 |
| Description of Target | Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) (PubMed:25310401). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus (PubMed:25893292). Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (PubMed:25893292). |
| Uniprot ID | P01137 |
| Protein Accession # | NP_000651.3 |
| Nucleotide Accession # | NM_000660.5 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "TGFB1 Antibody (OACD00156)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human|Mouse|Rat".
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How long will it take to receive "TGFB1 Antibody (OACD00156)"?
This item is available "Domestic: within 1-2 weeks delivery | International: within 1-2 weeks delivery".
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What buffer format is "TGFB1 Antibody (OACD00156)" provided in?
This item is provided in "Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "TGFB1 Antibody (OACD00156)"?
This target may also be called "CED;DPD1;IBDIMDE;LAP;latency-associated peptide;prepro-transforming growth factor beta-1;TGFB;TGFbeta;TGF-beta1;TGF-beta-1;transforming growth factor beta1;transforming growth factor beta-1 proprotein." in publications.
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What is the shipping cost for "TGFB1 Antibody (OACD00156)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "TGFB1 Antibody (OACD00156)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "TGFB1 Antibody (OACD00156)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "TGFB1 Antibody (OACD00156)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "TGFB1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "TGFB1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "TGFB1"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "TGFB1"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "TGFB1"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "TGFB1"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.
