SPTAN1 Antibody (Cleaved-Asp1185) (OASG06776)

Catalog No: OASG06776

Size:100 uL

Western Blot using Feline

Western Blot using HeLa

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB
• Additional Information: Cellular Localization: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells.
• Reconstitution and Storage: Store at -20°C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from the Internal region of human Spectrin Alpha II. Location: 1110-1190aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Cleaved-Asp1185
• Specificity: Cleaved-Spectrin Alpha II (D1185) Polyclonal Antibody detects endogenous levels of fragment of activated Spectrin Alpha II protein resulting from cleavage adjacent to D1185.
• Application Info: WB: 1:500~2000
  ELISA: 1:10000

Target Info

• Gene Symbol: SPTAN1
• Gene Full Name: spectrin, alpha, non-erythrocytic 1
• Alias Symbols: DEE5, NEAS, EIEE5, SPTA2
• NCBI Gene Id: 6709;
• Description of Target: Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.
• Uniprot ID: Q13813
• Molecular Weight: 137 kDa