SMARCA5 Antibody (OAAJ07218)

Catalog No: OAAJ07218

Size:100 uL

Western blot analysis of extracts of various celllines, using SMARCA5 antibody.

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB, IHC
• Reconstitution and Storage: Store at +4C. For long term storage, aliquot and store at -20C. Avoid freeze/thaw cycles.
• Immunogen: Recombinant protein of human SMARCA5
• Purification: Immunogen affinity chromatography
• Concentration: 1 mg/mL

Target Info

• Gene Symbol: SMARCA5
• Alias Symbols: ISWI, SNF2H, hISWI, hSNF2H, WCRF135
• NCBI Gene Id: 8467
• Protein Name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
• Description of Target: Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing.
• Uniprot ID: O60264
• Protein Accession #: NP_003592
• Nucleotide Accession #: NM_003601
• Molecular Weight: 122 kDa