SMAD6 Recombinant Protein (OPCD07069)

Catalog No: OPCD07069

SMAD6 Recombinant Protein (OPCD07069) using SDS-PAGE

SMAD6 Recombinant Protein (OPCD07069) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Cys261-Pro495
  Subcellular Location: Nucleus
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: SMAD6
• Gene Full Name: SMAD family member 6
• Alias Symbols: AOVD2;HsT17432;MAD homolog 6;MADH6;MADH7;mothers against decapentaplegic homolog 6;mothers against decapentaplegic, drosophila, homolog of, 6;SMAD family member 6;SMAD, mothers against DPP homolog 6.
• NCBI Gene Id: 4091
• Protein Name: Mothers against decapentaplegic homolog 6
• Description of Target: Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.
• Uniprot ID: O43541
• Protein Accession #: NP_005576.3
• Nucleotide Accession #: NM_005585.4
• Protein Size (# AA): Cys261~Pro495
• Molecular Weight: 33kDa