SMAD6 Recombinant Protein (OPCD07071)

Catalog No: OPCD07071

SMAD6 Recombinant Protein (OPCD07071) using SDS-PAGE

SMAD6 Recombinant Protein (OPCD07071) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Pro116-Gly364
  Subcellular Location: Nucleus
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 97%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Smad6
• Gene Full Name: SMAD family member 6
• Alias Symbols: b2b390C;b2b390Clo;MAD homolog 6;mad homolog 7;Madh;Madh6;mothers against decapentaplegic homolog 6;mothers against DPP homolog 6;Smad 6;SMAD family member 6.
• NCBI Gene Id: 17130
• Protein Name: Mothers against decapentaplegic homolog 6
• Description of Target: Binds to regulatory elements in target promoter regions (By similarity). May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding (By similarity). Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes.
• Uniprot ID: O35182
• Protein Accession #: NP_032568.3
• Nucleotide Accession #: NM_008542.3
• Protein Size (# AA): Gln171~Asp441
• Molecular Weight: 33kDa