Size:100 ul
Special Price $229.00 Regular Price $289.00
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ARP87140_P050
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SHC1 Antibody - middle region (ARP87140_P050)

Catalog#: ARP87140_P050
Domestic: within 24 hours delivery | International: 3-5 business days
More Information
Tested Species Reactivity Human
Predicted Species Reactivity Human
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality Polyclonal
Host Rabbit
Application WB
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human SHC1
Purification Affinity purified
Peptide Sequence Synthetic peptide located within the following region: ELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEP
Concentration Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide For anti-SHC1 (ARP87140_P050) antibody is Catalog # AAP87140
Datasheets/Manuals Printable datasheet for anti-SHC1 (ARP87140_P050) antibody
Gene Symbol SHC1
Official Gene Full Name SHC (Src homology 2 domain containing) transforming protein 1
Alias Symbols SHC, SHCA
NCBI Gene Id 6464
Protein Name SHC-transforming protein 1
Description of Target This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
Swissprot Id P29353-2
Protein Accession # NP_001123512.1
Nucleotide Accession # NM_001130040.1
Protein Size (# AA) 473
Molecular Weight 52 kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express SHC1.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express SHC1.
  1. What is the species homology for "SHC1 Antibody - middle region (ARP87140_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "SHC1 Antibody - middle region (ARP87140_P050)"?

    This item is available "Domestic: within 24 hours delivery | International: 3-5 business days".

  3. What buffer format is "SHC1 Antibody - middle region (ARP87140_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "SHC1 Antibody - middle region (ARP87140_P050)"?

    This target may also be called "SHC, SHCA" in publications.

  5. What is the shipping cost for "SHC1 Antibody - middle region (ARP87140_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "SHC1 Antibody - middle region (ARP87140_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "SHC1 Antibody - middle region (ARP87140_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "52 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "SHC1 Antibody - middle region (ARP87140_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "SHC1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "SHC1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "SHC1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "SHC1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "SHC1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "SHC1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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