Catalog No: ARP50490_P050
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ARP50490_P050
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Datasheets/ManualsPrintable datasheet for anti-SHC1 (ARP50490_P050) antibody
Product Info
Tested Species ReactivityHuman, Mouse
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the C terminal region of human SHC1
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
Peptide SequenceSynthetic peptide located within the following region: AEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQ
Concentration0.5 mg/ml
Blocking PeptideFor anti-SHC1 (ARP50490_P050) antibody is Catalog # AAP50490 (Previous Catalog # AAPY02818)
ReferenceGeorge,R., (2008) J. Mol. Biol. 377 (3), 740-747
Gene SymbolSHC1
Gene Full NameSHC (Src homology 2 domain containing) transforming protein 1
Alias SymbolsSHC, SHCA
NCBI Gene Id6464
Protein NameSHC-transforming protein 1
Description of TargetSHC1 is a signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span.
Uniprot IDP29353
Protein Accession #NP_003020
Nucleotide Accession #NM_003029
Protein Size (# AA)474
Molecular Weight52kDa
Protein InteractionsGRB2; Socs5; IGF1R; UBC; EGFR; Hgf; GAB2; GAB1; CBL; ERBB4; ERBB3; ERBB2; NEDD8; ZAP70; DOK1; KRT77; TUBB2B; TUBB; EEF1A1P5; ARAP1; TIMM50; UBASH3B; TUBA1C; PPP1R9B; TUBB6; ATAD3B; TUBA4B; TUBAL3; MYH14; LRRK1; TUBA8; RAB3GAP2; CORO1C; RUVBL2; CCT2; HAX1;
  1. What is the species homology for "SHC1 Antibody - C-terminal region (ARP50490_P050)"?

    The tested species reactivity for this item is "Human, Mouse". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish".

  2. How long will it take to receive "SHC1 Antibody - C-terminal region (ARP50490_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "SHC1 Antibody - C-terminal region (ARP50490_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "SHC1 Antibody - C-terminal region (ARP50490_P050)"?

    This target may also be called "SHC, SHCA" in publications.

  5. What is the shipping cost for "SHC1 Antibody - C-terminal region (ARP50490_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "SHC1 Antibody - C-terminal region (ARP50490_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "SHC1 Antibody - C-terminal region (ARP50490_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "52kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "SHC1 Antibody - C-terminal region (ARP50490_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "SHC1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "SHC1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "SHC1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "SHC1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "SHC1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "SHC1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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