RPL22 Antibody - C-terminal region (ARP63554_P050)

Catalog No: ARP63554_P050

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25 ug of the indicated Human whole cell extracts was loaded onto a 10-20% SDS-PAGE gel. 2 ug/mL of the antibody was used in this experiment. The protein may be modified by phosphorylation.

WB Suggested Anti-RPL22 Antibody
Titration: 1.0 ug/ml
Positive Control: Placenta

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
• Peptide Sequence: Synthetic peptide located within the following region: TSEVPFSKRYLKYLTKKYLKKNNLRDWLRVVANSKESYELRYFQINQDEE
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-RPL22 (ARP63554_P050) antibody is Catalog # AAP63554
• Enhanced Validation:

  Relative Expression (Western Blot)

Target Info

• Gene Symbol: RPL22
• Gene Full Name: Ribosomal protein L22
• Alias Symbols: EAP, L22, HBP15, HBP15/L22
• NCBI Gene Id: 6146
• Protein Name: 60S ribosomal protein L22
• Description of Target: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2.
• Uniprot ID: P35268
• Protein Accession #: NP_000974
• Nucleotide Accession #: NM_000983
• Protein Size (# AA): 128
• Molecular Weight: 15 kDa
• Protein Interactions: HUWE1; CEP76; CEP57; VCP; UBC; TUBG1; AURKA; RNF2; EED; HEXB; ARFGAP1; GTF3C4; PARK2; TARDBP; SRPK2; IGSF8; ICAM1; MAPK14; CDK2; CD81; PAN2; UBL4A; VCAM1; ITGA4; IL7R; FN1; SMURF1; ESR1; HNRNPM; RPSA; ILF3; HSP90AA4P; DHX15; RPLP0P6; RPL10L; RPS27L; STRAP