ROCK2 Recombinant Protein (OPCD06735)

Catalog No: OPCD06735

ROCK2 Recombinant Protein (OPCD06735) using SDS-PAGE

ROCK2 Recombinant Protein (OPCD06735) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Leu904-Gly1140
  Subcellular Location: Cytoplasm.聽Cell membrane;聽Peripheral membrane protein.聽Nucleus.聽Cytoskeleton, microtubule organizing center, centrosom
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: ROCK2
• Gene Full Name: Rho associated coiled-coil containing protein kinase 2
• Alias Symbols: p164 ROCK-2;Rho kinase 2;rho-associated protein kinase 2;Rho-associated, coiled-coil-containing protein kinase 2;rho-associated, coiled-coil-containing protein kinase II;ROCK-II.
• NCBI Gene Id: 9475
• Protein Name: Rho-associated protein kinase 2
• Description of Target: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.
• Uniprot ID: O75116
• Protein Accession #: NP_001308572.1
• Nucleotide Accession #: NM_001321643.1
• Protein Size (# AA): Leu904~Gly1140
• Molecular Weight: 31kDa