PSMA3 Antibody - middle region (ARP57742_P050)

Catalog No: ARP57742_P050

WB Suggested Anti-PSMA3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: 293T cell lysate

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PSMA3
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 92%; Rat: 92%; Yeast: 77%; Zebrafish: 77%
• Peptide Sequence: Synthetic peptide located within the following region: TCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREE
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-PSMA3 (ARP57742_P050) antibody is Catalog # AAP57742 (Previous Catalog # AAPP35445)
• Subunit: alpha type-3

Target Info

• Reference: Olsen,J.V., (2006) Cell 127 (3), 635-648
• Gene Symbol: PSMA3
• Gene Full Name: Proteasome (prosome, macropain) subunit, alpha type, 3
• Alias Symbols: HC8, PSC3
• NCBI Gene Id: 5684
• Protein Name: Proteasome subunit alpha type-3
• Description of Target: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMA3 is a member of the peptidase T1A family, that is a 20S core alpha subunit.The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.
• Uniprot ID: P25788-2
• Protein Accession #: NP_687033
• Nucleotide Accession #: NM_152132
• Protein Size (# AA): 248
• Molecular Weight: 28kDa
• Protein Interactions: SF1; STX4; SNRPC; SNRPB; RAB3IL1; PSMB4; PSMA6; PSMA3; PSMA1; NPPB; CTAGE5; LETM1; LASP1; KRAS; NPBWR2; GATA3; GATA2; CYBA; CST2; CDK6; ATP6V0C; DMC1; SLMO1; BTN2A2; STX6; SERF2; HUWE1; APLN; C1QTNF9B-AS1; C9orf106; KRTAP26-1; KRTAP19-5; KRTAP8-1; RTP5; R