PDK1 Recombinant Protein (OPCD06086)

Catalog No: OPCD06086

PDK1 Recombinant Protein (OPCD06086) using SDS-PAGE

PDK1 Recombinant Protein (OPCD06086) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Tyr233-Met430
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: PDK1
• Gene Full Name: pyruvate dehydrogenase kinase 1
• Alias Symbols: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial;mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1;PDH kinase 1;pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial;Pyruvate dehydrogenase kinase isoform 1;pyruvate dehydrogenase kinase, isoenzyme 1.
• NCBI Gene Id: 5163
• Protein Name: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
• Description of Target: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
• Uniprot ID: Q15118
• Protein Accession #: NP_001265478.1
• Nucleotide Accession #: NM_001278549.1
• Protein Size (# AA): Tyr233~Met430
• Molecular Weight: 27kDa