MMP24 Recombinant Protein (OPCD05337)

Catalog No: OPCD05337

MMP24 Recombinant Protein (OPCD05337) using SDS-PAGE

MMP24 Recombinant Protein (OPCD05337) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ile429-Gln642
  Subcellular Location: Cell membrane; Single-pass type I membrane protein; Extracellular side. Secreted, extracellular space, extracellular matr
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 90%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: MMP24
• Gene Full Name: matrix metallopeptidase 24
• Alias Symbols: matrix metallopeptidase 24 (membrane-inserted);matrix metalloproteinase 24 (membrane-inserted);matrix metalloproteinase-24;membrane-type 5 matrix metalloproteinase;membrane-type matrix metalloproteinase 5;Membrane-type-5 matrix metalloproteinase;MMP-24;MMP25;MT5MMP;MT5-MMP;MT-MMP 5;MTMMP5;MT-MMP5.
• NCBI Gene Id: 10893
• Protein Name: Matrix metalloproteinase-24
• Description of Target: Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity).
• Uniprot ID: Q9Y5R2
• Protein Accession #: NP_006681.1
• Nucleotide Accession #: NM_006690.3
• Protein Size (# AA): Ile429~Gln642
• Molecular Weight: 29kDa