MEF2C Antibody (OAAB03437)

Catalog No: OAAB03437

Size:400ul

Western blot analysis of MEF2C (arrow) using rabbit polyclonal MEF2C Antibody (S59) (RB11081). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or lysates transiently transfected transfected with the MEF2C gene (Lane 2) (Origene Technologies).

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Mouse, Rat, Zebrafish, Bovine, Chicken, Pig, Xenopus
• Product Format: Liquid. PBS with 0.09% (W/V) sodium azide
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Host: Rabbit
• Application: WB, E
• Additional Information: Function: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
  Cellular Location: Nucleus {ECO:0000250|UniProtKB:A0A096MJY4}. Cytoplasm, sarcoplasm {ECO:0000250|UniProtKB:A0A096MJY4}
  Tissue Location: Expressed in brain and skeletal muscle.
• Reconstitution and Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This MEF2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-66 amino acids from human MEF2C.
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: 0.5 mg/ml
• Intended Use: For research use only and not for use in diagnostic or therapeutic procedures.
• Application Info: WB: 1:1,000
  Optimal dilutions should be determined by the end user.
• Reference: Konig, S., et al., J. Biol. Chem. 279(27):28187-28196 (2004).
  Maeda, T., et al., J. Biol. Chem. 277(50):48889-48898 (2002).
  Maeda, T., et al., Biochem. Biophys. Res. Commun. 294(4):791-797 (2002).
  Janson, C.G., et al., Brain Res. Mol. Brain Res. 97(1):70-82 (2001).
  Krainc, D., et al., Genomics 29(3):809-811 (1995).

Target Info

• Gene Symbol: MEF2C
• Alias Symbols: DEL5q14.3, C5DELq14.3
• NCBI Gene Id: 4208
• Protein Name: Myocyte-specific enhancer factor 2C
• Description of Target: MEF2C is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. This protein controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. It may also be involved in neurogenesis and in the development of cortical architecture.
• Uniprot ID: Q06413
• Protein Accession #: NP_001124477.1
• Molecular Weight: 51 kDa