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Catalog No: OAAB03437
Size:400ul
Price: $438.00
SKU
OAAB03437
Availability: Domestic: within 1-2 week delivery | International: within 1-2 week delivery
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Datasheets/ManualsPrintable datasheet for anti-MEF2C antibody - OAAB03437
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityMouse, Rat, Zebrafish, Bovine, Chicken, Pig, Xenopus
Product FormatLiquid. PBS with 0.09% (W/V) sodium azide
ClonalityPolyclonal
IsotypeRabbit Ig
HostRabbit
ApplicationWB
Additional InformationFunction: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
::Cellular Location: Nucleus {ECO:0000250|UniProtKB:A0A096MJY4}. Cytoplasm, sarcoplasm {ECO:0000250|UniProtKB:A0A096MJY4}
Tissue Location: Expressed in brain and skeletal muscle.
Reconstitution and StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThis MEF2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-66 amino acids from human MEF2C.
PurificationThis antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration0.5 mg/ml
Intended UseFor research use only and not for use in diagnostic or therapeutic procedures.
Application InfoWB: 1:1,000
Optimal dilutions should be determined by the end user.
ReferenceKonig, S., et al., J. Biol. Chem. 279(27):28187-28196 (2004).
Maeda, T., et al., J. Biol. Chem. 277(50):48889-48898 (2002).
Maeda, T., et al., Biochem. Biophys. Res. Commun. 294(4):791-797 (2002).
Janson, C.G., et al., Brain Res. Mol. Brain Res. 97(1):70-82 (2001).
Krainc, D., et al., Genomics 29(3):809-811 (1995).
Gene SymbolMEF2C
Alias SymbolsDEL5q14.3, C5DELq14.3
NCBI Gene Id4208
Protein NameMyocyte-specific enhancer factor 2C
Description of TargetMEF2C is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. This protein controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. It may also be involved in neurogenesis and in the development of cortical architecture.
Uniprot IDQ06413
Protein Accession #NP_001124477.1
Molecular Weight51 kDa
  1. What is the species homology for "MEF2C Antibody (OAAB03437)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Mouse, Rat, Zebrafish, Bovine, Chicken, Pig, Xenopus".

  2. How long will it take to receive "MEF2C Antibody (OAAB03437)"?

    This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".

  3. What buffer format is "MEF2C Antibody (OAAB03437)" provided in?

    This item is provided in "Liquid. PBS with 0.09% (W/V) sodium azide".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "MEF2C Antibody (OAAB03437)"?

    This target may also be called "DEL5q14.3, C5DELq14.3" in publications.

  5. What is the shipping cost for "MEF2C Antibody (OAAB03437)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "MEF2C Antibody (OAAB03437)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "MEF2C Antibody (OAAB03437)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "51 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "MEF2C Antibody (OAAB03437)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "MEF2C"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "MEF2C"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "MEF2C"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "MEF2C"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "MEF2C"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "MEF2C"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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