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MBD2 Antibody - N-terminal region (ARP32485_P050)

100 ul
$289.00
In Stock
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Conjugation Options

ARP32485_P050-FITC Conjugated

ARP32485_P050-HRP Conjugated

ARP32485_P050-Biotin Conjugated

Tested Species Reactivity:
Human, Mouse
Predicted Species Reactivity:
Human, Mouse, Rat
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality:
Polyclonal
Host:
Rabbit
Application:
WB, IHC
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
MBD2
Official Gene Full Name:
Methyl-CpG binding domain protein 2
NCBI Gene Id:
8932
Protein Name:
Methyl-CpG-binding domain protein 2
Swissprot Id:
Q9UBB5
Protein Accession #:
NP_056647
Nucleotide Accession #:
NM_015832
Alias Symbols:
DKFZp586O0821, DMTase, NY-CO-41
Replacement Item:
This antibody may replace item sc-10752 from Santa Cruz Biotechnology.
Description of Target:
MBD2 belongs to a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD2 can also repress transcription from methylated gene promoters. MBD2 may function as a mediator of the biological consequences of the methylation signal.It is also reported that the MBD2 functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.
Protein Size (# AA):
302
Molecular Weight:
32kDa
Purification:
Affinity Purified
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express MBD2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express MBD2.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human MBD2
Predicted Homology Based on Immunogen Sequence:
Human: 100%; Mouse: 100%; Rat: 100%
Complete computational species homology data:
Anti-MBD2 (ARP32485_P050)
Peptide Sequence:
Synthetic peptide located within the following region: RAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRR
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
UBC; SOX2; HDAC2; HDAC1; MTA3; LAMTOR3; TFAP4; KDM5B; CDK2AP1; ESR1; KDM1A; MTA2; MBD2; RBBP7; RBBP4; CHD3; tat; MBD3L2; MBD3; csul; GATAD2A; TACC3; PRMT5; WDR77; PRMT1; PTK2B; TRIM27; GATAD2B; MBD3L1; GPN1; SIN3A; HINFP; DHX9; CREBBP; DNMT1; tax; NEWENTR
Blocking Peptide:
For anti-MBD2 (ARP32485_P050) antibody is Catalog # AAP32485 (Previous Catalog # AAPP03484)
Datasheets/Manuals:
Printable datasheet for anti-MBD2 (ARP32485_P050) antibody
Sample Type Confirmation:

MBD2 is strongly supported by BioGPS gene expression data to be expressed in 721_B

Target Reference:
Xing,J., (2008) Br. J. Cancer 98 (10), 1716-1722
Publications:

Jungwirth, M., Dear, M. L., Brown, P., Holbrook, K. & Goodchild, R. Relative tissue expression of homologous torsinB correlates with the neuronal specific importance of DYT1 dystonia-associated torsinA. Hum. Mol. Genet. 19, 888-900 (2010). WB, IHC, Human, Mouse, Rat 20034025

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