Size:100 ul
Special Price $229.00 Regular Price $289.00
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ARP32485_P050
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Conjugation Options

ARP32485_P050-FITC Conjugated

ARP32485_P050-HRP Conjugated

ARP32485_P050-Biotin Conjugated

MBD2 Antibody - N-terminal region (ARP32485_P050)

Catalog#: ARP32485_P050
Domestic: within 1-2 days delivery | International: 1-2 days
More Information
Tested Species Reactivity Human, Mouse
Predicted Species Reactivity Human, Mouse, Rat
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality Polyclonal
Host Rabbit
Application WB, IHC
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-10752 from Santa Cruz Biotechnology.
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human MBD2
Purification Affinity Purified
Predicted Homology Based on Immunogen Sequence Human: 100%; Mouse: 100%; Rat: 100%
Complete computational species homology data Anti-MBD2 (ARP32485_P050)
Peptide Sequence Synthetic peptide located within the following region: RAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRR
Concentration Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide For anti-MBD2 (ARP32485_P050) antibody is Catalog # AAP32485 (Previous Catalog # AAPP03484)
Datasheets/Manuals Printable datasheet for anti-MBD2 (ARP32485_P050) antibody
Sample Type Confirmation

MBD2 is strongly supported by BioGPS gene expression data to be expressed in 721_B

Target Reference Xing,J., (2008) Br. J. Cancer 98 (10), 1716-1722
Publications

Jungwirth, M., Dear, M. L., Brown, P., Holbrook, K. & Goodchild, R. Relative tissue expression of homologous torsinB correlates with the neuronal specific importance of DYT1 dystonia-associated torsinA. Hum. Mol. Genet. 19, 888-900 (2010). WB, IHC, Human, Mouse, Rat 20034025

Gene Symbol MBD2
Official Gene Full Name Methyl-CpG binding domain protein 2
Alias Symbols DKFZp586O0821, DMTase, NY-CO-41
NCBI Gene Id 8932
Protein Name Methyl-CpG-binding domain protein 2
Description of Target MBD2 belongs to a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD2 can also repress transcription from methylated gene promoters. MBD2 may function as a mediator of the biological consequences of the methylation signal.It is also reported that the MBD2 functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.
Swissprot Id Q9UBB5
Protein Accession # NP_056647
Nucleotide Accession # NM_015832
Protein Size (# AA) 302
Molecular Weight 32kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express MBD2.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express MBD2.
Protein Interactions UBC; SOX2; HDAC2; HDAC1; MTA3; LAMTOR3; TFAP4; KDM5B; CDK2AP1; ESR1; KDM1A; MTA2; MBD2; RBBP7; RBBP4; CHD3; tat; MBD3L2; MBD3; csul; GATAD2A; TACC3; PRMT5; WDR77; PRMT1; PTK2B; TRIM27; GATAD2B; MBD3L1; GPN1; SIN3A; HINFP; DHX9; CREBBP; DNMT1; tax; NEWENTR
  1. What is the species homology for "MBD2 Antibody - N-terminal region (ARP32485_P050)"?

    The tested species reactivity for this item is "Human, Mouse". This antibody is predicted to have homology to "Human, Mouse, Rat".

  2. How long will it take to receive "MBD2 Antibody - N-terminal region (ARP32485_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "MBD2 Antibody - N-terminal region (ARP32485_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "MBD2 Antibody - N-terminal region (ARP32485_P050)"?

    This target may also be called "DKFZp586O0821, DMTase, NY-CO-41" in publications.

  5. What is the shipping cost for "MBD2 Antibody - N-terminal region (ARP32485_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "MBD2 Antibody - N-terminal region (ARP32485_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "MBD2 Antibody - N-terminal region (ARP32485_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "32kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "MBD2 Antibody - N-terminal region (ARP32485_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "MBD2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "MBD2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "MBD2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "MBD2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "MBD2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "MBD2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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