KEAP1 Recombinant Protein (OPCD04650)

Catalog No: OPCD04650

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Met1-Gln286
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 97%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Keap1
• Gene Full Name: kelch-like ECH-associated protein 1
• Alias Symbols: cytosolic inhibitor of Nrf2;IN;INRF2;kelch-like ECH-associated protein 1;mKIAA0132;NRF2 cytosolic inhibitor;ring canal protein.
• NCBI Gene Id: 50868
• Protein Name: Kelch-like ECH-associated protein 1
• Description of Target: Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).
• Uniprot ID: Q9Z2X8
• Protein Accession #: NP_001103775.1
• Nucleotide Accession #: NM_001110305.1
• Protein Size (# AA): Met1~Gln286
• Molecular Weight: 36kDa