KARS Recombinant Protein (OPCD04640)

Catalog No: OPCD04640

KARS Recombinant Protein (OPCD04640) using SDS-PAGE

KARS Recombinant Protein (OPCD04640) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Arg323-Arg553
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: KARS1
• Gene Full Name: lysyl-tRNA synthetase 1
• Alias Symbols: CMTRIB;DEAPLE;DFNB89;KARS;KARS2;KRS;LEPID;lysine tRNA ligase;lysine--tRNA ligase;lysRS;Lysyl-tRNA synthetase.
• NCBI Gene Id: 3735
• Protein Name: Lysine--tRNA ligase
• Description of Target: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:9278442, PubMed:18029264, PubMed:18272479). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:5338216, PubMed:14975237, PubMed:19524539, PubMed:23159739).
• Uniprot ID: Q15046
• Protein Accession #: NP_001123561.1
• Nucleotide Accession #: NM_001130089.1
• Protein Size (# AA): Arg323~Arg553
• Molecular Weight: 30kDa