- Toll Free: 888-880-0001
- Phone: 858-552-6979
- Email: info@avivasysbio.com
- $55: Antibody & Protein in US
- $55 + $25/Kit in US
- Contact us for international orders.
| Datasheets/Manuals | Printable datasheet for anti-IL-10 (OADB00314) antibody |
|---|
| Predicted Species Reactivity | Human |
|---|---|
| Product Format | Lyophilized |
| Clonality | Monoclonal |
| Clone | B-S10 |
| Isotype | Mouse IgG1 |
| Host | Mouse |
| Application | BL |
| Reconstitution and Storage | Store at +2-8C for 12 months. For longer storage, freeze aliquots |
| Purification | Ion exchange chromatography |
| Concentration | 1 ug/uL |
| Specificity | Recognises both natural and recombinant human IL-10 |
| Formulation | Phosphate-buffered saline. Sterile-filtered through 0.22 um and treated to remove endotoxins. Carrier and preservative free |
| Storage Buffer | Phosphate-buffered saline. Sterile-filtered through 0.22 um and treated to remove endotoxins. Carrier and preservative free |
| Reference | Balashov, K. E. et al., Neurology,2000; 55(2): 192-8. Brok, H. P. et al., J Immunol.,2002; 169(11): 6554-63. Debili, N.et al. Blood,2001; 97(7): 2023-2030. Egeler, R. M. et al., Blood,1999; 94(12): 4195-201. Fontana, S. et al., Blood,2003; 102(12): 4099-106. Jarry, A. et al., J. Clin. Invest., 2008;118(3):1132-42 Lelievre, E. et al., Cytokine,1998; 10(11): 831-40. Naji, A. et al., Blood,2007;110(12):3936-48 Ravirajan C.T. et al., 2004; 43(4) : 442 - 447 Schandene, L. et al., J Immunol.,1994; 152(9): 4368-74. Schrijver, I. A. et al., Brain,2001; 124(Pt 8): 1544-54. Villoslada, P. et al.,J Exp Med.,2000; 191(10): 1799-806. |
| Biological Activity | Blocks IL-10 induced proliferation on MC/9 cell line |
| Gene Symbol | IL-10 |
|---|---|
| Gene Full Name | interleukin 10 |
| Alias Symbols | CSIF, TGIF, GVHDS, IL-10, IL10A |
| NCBI Gene Id | 3586 |
| Protein Name | interleukin-10 |
| Description of Target | The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. |
| Uniprot ID | P22301 |
| Protein Accession # | NP_000563.1 |
| Nucleotide Accession # | NM_000572.2 |
| Molecular Weight | 21 kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
-
See our General FAQ page.
-
What is the species homology for "IL-10 Antibody (OADB00314)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
-
How long will it take to receive "IL-10 Antibody (OADB00314)"?
This item is available "Domestic: within 1-2 weeks delivery ,International: within 1-2 weeks delivery".
-
What buffer format is "IL-10 Antibody (OADB00314)" provided in?
This item is provided in "Lyophilized".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "IL-10 Antibody (OADB00314)"?
This target may also be called "CSIF, TGIF, GVHDS, IL-10, IL10A" in publications.
-
What is the shipping cost for "IL-10 Antibody (OADB00314)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
-
What is the guarantee for "IL-10 Antibody (OADB00314)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
-
Can I get bulk pricing for "IL-10 Antibody (OADB00314)"?
You can get bulk pricing for this item by going here.
-
What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "21 kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "IL-10 Antibody (OADB00314)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
-
What are positive controls for "IL-10"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
-
What are negative controls for "IL-10"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
-
What other proteins interact with "IL-10"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
-
What biological processes are associated with "IL-10"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
-
What cellular components are associated with "IL-10"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
-
What protein functions are associated with "IL-10"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.
