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I23O2 Antibody - C-terminal region (OAAB08672)

400ul
$390.00
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Gene Symbol:
IDO2
NCBI Gene Id:
169355
Protein Name:
Indoleamine 2,3-dioxygenase 2
Swissprot Id:
Q6ZQW0
Protein Accession #:
NP_919270.2
Alias Symbols:
IDO2, INDOL1, Indoleamine 2,3-dioxygenase 2, Indoleamine 2,3-dioxygenase-like protein 1, Indoleamine-pyrrole 2,3-dioxygenase-like protein 1
Replacement Item:
This antibody may replace item sc-292211 from Santa Cruz Biotechnology.
Description of Target:
Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway.
Molecular Weight:
47 kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Application:
WB, IHC-P, ELISA
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express IDO2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express IDO2.
Immunogen:
This I23O2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-295 amino acids from the C-terminal region of human I23O2.
Predicted Species Reactivity:
Human
Product Format:
Liquid PBS with 0.09% (W/V) sodium azide.
Reconstitution and Storage:
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Concentration:
0.5 mg/ml
Datasheets/Manuals:
Printable datasheet for OAAB08672
Isotype:
Ig
Intended Use:
I23O2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Application Info:
IHC-P: 1:10~50
WB: 1:1000
Additional Information:
Function: Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance.
Tissue Location: Detected in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon. Also expressed at low level in testis and thyroid. Not expressed in the majority of human tumor samples (>99%).
Publications:

Guastella, AR; Michelhaugh, SK; Klinger, NV; Kupsky, WJ; Polin, LA; Muzik, O; Juhász, C; Mittal, S; Tryptophan PET Imaging of the Kynurenine Pathway in Patient-Derived Xenograft Models of Glioblastoma.. 15, (2016). WB, IHC-P, Human 27151136

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