I23O2 Antibody - C-terminal region (OAAB08672)

• Product Number: OAAB08672
• Name: I23O2 Antibody - C-terminal region (OAAB08672)
• Molecular Weight: 47075
• Isotype: Ig
• NCBI Gene Id: 169355
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.45 mg/ml
• Gene Full Name: indoleamine 2,3-dioxygenase 2
• Description:
  View product citations for I23O2 Antibody - C-terminal region (OAAB08672) on CiteAb
• Alias Symbols: INDOL1;indoleamine 2,3-dioxygenase 2;indoleamine 2,3-dioxygenase-like 1 protein;indoleamine 2,3-dioxygenase-like protein 1;indoleamine-pyrrole 2,3 dioxygenase-like 1;indoleamine-pyrrole 2,3-dioxygenase-like protein 1.
• Product Format: Liquid PBS with 0.09% (W/V) sodium azide.
• Reference: Cetindere, T., et al. Cell. Signal. 22(2):197-211(2010)
  Huttunen, R., et al. Shock 33(2):149-154(2010)
  Witkiewicz, A.K., et al. J. Am. Coll. Surg. 208(5):781-787(2009)
  Metz, R., et al. Cancer Res. 67(15):7082-7087(2007)
  Ball, H.J., et al. Gene 396(1):203-213(2007)
• Description of Target: Indoleamine 2,3-dioxygenase 2, indoleamine 2,3-dioxygenase 2 [Homo sapiens]
• Reconstitution and Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Additional Information: Tissue Location: Detected in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon. Also expressed at low level in testis and thyroid. Not expressed in the majority of human tumor samples (>99%).
• Application Info: IHC-P: 1:10~50
  WB: 1:2000
  Optimal dilutions should be determined by the end user.
• Immunogen: This I23O2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-295 amino acids from the C-terminal region of human I23O2.
• Intended Use: I23O2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
• Uniprot ID: https://www.uniprot.org/uniprot/Q6ZQW0
• Protein Name: NP_919270.2, Q6ZQW0
• Publications:

  Investigation of the aryl hydrocarbon receptor and the intrinsic tumoral component of the kynurenine pathway of tryptophan metabolism in primary brain tumors. J Neurooncol. 139, 239-249 (2018). 29667084

  Molecular imaging correlates of tryptophan metabolism via the kynurenine pathway in human meningiomas. Neuro Oncol. 17, 1284-92 (2015). 26092774

  Tryptophan PET Imaging of the Kynurenine Pathway in Patient-Derived Xenograft Models of Glioblastoma. Mol Imaging. 15, (2016). 27151136

• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/NP_919270.2
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Gene Symbol: IDO2
• Predicted Species Reactivity: Human
• Application: Immunohistochemistry-Paraffin, Western blot
• Image 1: Human Liver
  
  I23O2 Antibody (C-term) (Cat. #OAAB08672)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of I23O2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
• Image 2: K562
  
  I23O2 Antibody (C-term) (Cat. #OAAB08672) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the I23O2 antibody detected the I23O2 protein (arrow).