GPR56 Antibody (OAAF04956)

Catalog No: OAAF04956 (Formerly GWB-ASF350)

Size:100 ug

Western blot analysis of extracts from K562 cells, using GPR56 Antibody. The lane on the right is treated with the synthesized peptide.

Immunofluorescence analysis of MCF7 cells, using GPR56 Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human GPR56.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: GPR56 antibody detects endogenous levels of total GPR56 protein.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: WB: 1:500~1:3000; IF: 1:100~1:500; ELISA: 1:20000
• Reference: Liu M., Genomics 55:296-305(1999).
  Zendman A.J.W., FEBS Lett. 446:292-298(1999).
  Clark H.F., Genome Res. 13:2265-2270(2003).

Target Info

• Gene Symbol: ADGRG1
• Gene Full Name: adhesion G protein-coupled receptor G1
• Alias Symbols: 7-transmembrane protein with no EGF-like N-terminal domains-1;adhesion G-protein coupled receptor G1;BFPP;BPPR;G protein-coupled receptor 56;GPR56;G-protein coupled receptor 56;Protein TM7XN1;testicular tissue protein Li 77;TM7LN4;TM7XN1.
• NCBI Gene Id: 9289
• Protein Name: Adhesion G-protein coupled receptor G1
• Description of Target: Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (By similarity). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (PubMed:22238662). Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (By similarity). Plays a critical role in cancer progression by inhibiting VEGFA production threreby inhibiting angiogenesis through a signaling pathway mediated by PRKCA (PubMed:16757564, PubMed:21724588). Plays an essential role in testis development (By similarity).
• Uniprot ID: Q9Y653
• Protein Accession #: NP_001139242.1
• Molecular Weight: 77 kDa