FZD5 Antibody (OABF01116)

Catalog No: OABF01116

Size:100UL

L1 rat lung lysates, L2 rat brain lysates probed (OABF01116) Anti-Frizzled-5 Polyclonal, Unconjugated at 1:200 in 4C. Followed by conjugation to secondary antibody at 1:3000 90min in 37C. Predicted band and observed band size: 62kD.

Product Info

• Predicted Species Reactivity: Bovine|Dog|Human|Mouse|Porcine|Rabbit|Rat
• Product Format: Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Flow cytometry|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Western blot
• Additional Information: Subcellular location: Extracellular
• Reconstitution and Storage: -20°C
• Immunogen: KLH conjugated synthetic peptide derived from human Frizzled 5
• Purification: Protein A Purified
• Concentration: 1 ug/ul
• Application Info: WB: 1:100 - 1000
  IHC-P: : 1:100 - 500

Target Info

• Gene Symbol: FZD5|FZD8
• Gene Full Name: frizzled class receptor 5|frizzled class receptor 8
• Alias Symbols: C2orf31;frizzled 5, seven transmembrane spanning receptor;frizzled 8, seven transmembrane spanning receptor;frizzled family receptor 5;frizzled family receptor 8;frizzled homolog 8;frizzled-5;frizzled-8;fz-5;FZ-8;fzE5;HFZ5;hFZ8;seven-transmembrane receptor frizzled-5;Wnt receptor.
• NCBI Gene Id: 7855|8325
• Description of Target: Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The Frizzled 5 protein is believed to be the receptor for the Wnt5A ligand. Frizzled 5 has been reported to be expressed in fetal kidney, fetal and adult liver, fetal lung, and adult pancreas. ESTs have been isolated from bone, liver/spleen, placenta, and prostate libraries. Frizzled 5 was cloned from a retina cDNA library. Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.