FTCD Protein (OPPA00822)

Catalog No: OPPA00822 (Formerly GWB-802F40)

Size:5UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: FTCD is supplied at a concentration of 0.5mg/ml in 16mM HEPES buffer pH-7.6, 240mM sodium chloride, and 20% glycerol.
• Host: Sf9 Insect Cells
  Immunological Functions: 1. Binds IgG-type human auto-antibodies.2. Standard ELISA test (checker-board analysis of positive/negative sera panels, immuno-dot test).
  Product Introduction: Formiminotransferase cyclodeaminase is an enzyme which catalyzes the conversion of formiminoglutamateand tetrahydrofolateinto formiminotetrahydrofolateand glutamate.Formiminotransferase cyclodeaminase, a bifunctional enzyme of tetrahydrofolate synthesis, is the target antigen of anti-LC1 (liver cytosol antigen type 1) autoantibodies. Presence of LC1 autoantibodies is a marker for type 2 autoimmune hepatitis (for which anti-LKM 1/cytochrome P450 2D6 autoantibodies are a further marker).Serum LC1 autoantibody concentrations appear to fluctuate in parallel with aminotransferase levels, a particularly intriguing observation that suggests a possible role of LC1 autoreactivity in the pathogenic mechanism leading to hepatocyte injury.
• Reconstitution and Storage: Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20Cfor longer periods of time. Avoid multiple freeze-thaw cycles.
• Purity: Greater than 95% as determined by SDS-PAGE.
• Application Info: Coating Concentration: 0.35-0.7 ug/ml (depending on the type of ELISA plate and coating buffer). Suitable for biotinylation and iodination.

Target Info

• Gene Symbol: FTCD
• Alias Symbols: LCHC1
• NCBI Gene Id: 10841
• Protein Name: Formimidoyltransferase-cyclodeaminase
• Description of Target: Formiminotransferase Cyclodeaminase Human Recombinant (also called liver cytosol type 1) produced in SF9, is a glycosylated, polypeptide chain having a molecular mass of 59,749 Dalton.The FTCD is expressed with a -6xHis tag and purified by proprietary chromatographic techniques.
• Uniprot ID: O95954
• Protein Accession #: NP_006648.1
• Protein Size (# AA): Recombinant