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- $55: Antibody & Protein in US
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| Datasheets/Manuals | Printable datasheet for FGF1 Antibody (OACA06749) (OACA06749) |
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| Predicted Species Reactivity | Human |
|---|---|
| Product Format | Liquid |
| Clonality | Polyclonal |
| Isotype | IgG |
| Host | Rabbit |
| Conjugation | Unconjugated |
| Application | Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry |
| Reconstitution and Storage | -20°C or -80°C |
| Immunogen | Recombinant Human Fibroblast growth factor 1 protein (16-155AA) |
| Purification | Affinity Purified |
| Preservative | 0.02% sodium azide |
| Formulation | PBS with, 50% glycerol, pH7.3. |
| Reference | [1]The heterohexameric complex structure, a component in the non-classical pathway for fibroblast growth factor 1 (FGF1) secretion."Mohan S.K., Rani S.G., Yu C.J. Biol. Chem. 285:15464-15475(2010). [2]Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors." Fernandez I.S., Cuevas P., Angulo J., Lopez-Navajas P., Canales-Mayordomo A., Gonzalez-Corrochano R., Lozano R.M., Valverde S., Jimenez-Barbero J., Romero A., Gimenez-Gallego G.J. Biol. Chem. 285:11714-11729(2010). [3]Solution structure of acidic fibroblast growth factor bound to 1,3, 6-naphthalenetrisulfonate: a minimal model for the anti-tumoral action of suramins and suradistas." Lozano R.M., Jimenez M., Santoro J., Rico M., Gimenez-Gallego G.J. Mol. Biol. 281:899-915(1998). |
| Gene Symbol | FGF1 |
|---|---|
| Gene Full Name | fibroblast growth factor 1 |
| Alias Symbols | Acidic fibroblast growth factor;AFGF;beta-endothelial cell growth factor;ECGF;ECGFA;ECGFB;ECGF-beta;Endothelial cell growth factor;endothelial cell growth factor, alpha;endothelial cell growth factor, beta;FGF-1;FGFA;FGF-alpha;fibroblast growth factor 1;fibroblast growth factor 1 (acidic);GLIO703;HBGF1;HBGF-1;heparin-binding growth factor 1. |
| NCBI Gene Id | 2246 |
| Protein Name | Fibroblast growth factor 1 |
| Description of Target | Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107). |
| Uniprot ID | P05230 |
| Protein Accession # | NP_000791 |
| Nucleotide Accession # | NM_000800 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "FGF1 Antibody (OACA06749)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "FGF1 Antibody (OACA06749)"?
This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".
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What buffer format is "FGF1 Antibody (OACA06749)" provided in?
This item is provided in "Liquid".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "FGF1 Antibody (OACA06749)"?
This target may also be called "Acidic fibroblast growth factor;AFGF;beta-endothelial cell growth factor;ECGF;ECGFA;ECGFB;ECGF-beta;Endothelial cell growth factor;endothelial cell growth factor, alpha;endothelial cell growth factor, beta;FGF-1;FGFA;FGF-alpha;fibroblast growth factor 1;fibroblast growth factor 1 (acidic);GLIO703;HBGF1;HBGF-1;heparin-binding growth factor 1." in publications.
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What is the shipping cost for "FGF1 Antibody (OACA06749)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "FGF1 Antibody (OACA06749)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "FGF1 Antibody (OACA06749)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "FGF1 Antibody (OACA06749)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "FGF1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "FGF1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "FGF1"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "FGF1"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "FGF1"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "FGF1"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.
