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| Datasheets/Manuals | Printable datasheet for FGF-1 Antibody (OAAF05749) |
|---|
| Predicted Species Reactivity | Human|Mouse|Rat |
|---|---|
| Clonality | Polyclonal |
| Host | Rabbit |
| Application | Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin |
| Reconstitution and Storage | -20°C |
| Immunogen | The antiserum was produced against synthesized peptide derived from human FGF-1. |
| Purification | The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen. |
| Concentration | 1 mg/ml |
| Specificity | FGF-1 antibody detects endogenous levels of FGF-1. |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application Info | IHC: 1:50 - 1:100 ELISA: 1:10000 |
| Gene Symbol | FGF1 |
|---|---|
| Gene Full Name | fibroblast growth factor 1 |
| Alias Symbols | Acidic fibroblast growth factor;AFGF;beta-endothelial cell growth factor;ECGF;ECGFA;ECGFB;ECGF-beta;Endothelial cell growth factor;endothelial cell growth factor, alpha;endothelial cell growth factor, beta;FGF-1;FGFA;FGF-alpha;fibroblast growth factor 1;fibroblast growth factor 1 (acidic);GLIO703;HBGF1;HBGF-1;heparin-binding growth factor 1. |
| NCBI Gene Id | 2246 |
| Protein Name | Fibroblast growth factor 1 |
| Description of Target | Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107). |
| Uniprot ID | P05230 |
| Molecular Weight | 17 kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "FGF-1 Antibody (OAAF05749)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human|Mouse|Rat".
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How long will it take to receive "FGF-1 Antibody (OAAF05749)"?
This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".
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What buffer format is "FGF-1 Antibody (OAAF05749)" provided in?
This item is provided in "".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "FGF-1 Antibody (OAAF05749)"?
This target may also be called "Acidic fibroblast growth factor;AFGF;beta-endothelial cell growth factor;ECGF;ECGFA;ECGFB;ECGF-beta;Endothelial cell growth factor;endothelial cell growth factor, alpha;endothelial cell growth factor, beta;FGF-1;FGFA;FGF-alpha;fibroblast growth factor 1;fibroblast growth factor 1 (acidic);GLIO703;HBGF1;HBGF-1;heparin-binding growth factor 1." in publications.
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What is the shipping cost for "FGF-1 Antibody (OAAF05749)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "FGF-1 Antibody (OAAF05749)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "FGF-1 Antibody (OAAF05749)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "17 kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "FGF-1 Antibody (OAAF05749)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "FGF1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "FGF1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "FGF1"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "FGF1"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "FGF1"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "FGF1"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.
