Catalog No: OPCD03874
Price: $0.00
SKU
OPCD03874
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Datasheets/Manuals | Printable datasheet for EPAS1 Recombinant Protein (OPCD03874) |
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Predicted Species Reactivity | Mouse|Mus musculus |
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Product Format | Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose. |
Host | E.coli |
Conjugation | Unconjugated |
Application | Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot |
Additional Information | Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method) |
:: | Residues: Asp21-Cys336 |
Reconstitution and Storage | 2°C to 8°C|-80°C |
Concentration | 200 ug/mL (prior to lyoph) |
Purity | > 95% |
Source | E.coli |
Tag | N-terminal His Tag |
Gene Symbol | Epas1 |
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Gene Full Name | endothelial PAS domain protein 1 |
Alias Symbols | bHLHe7;bHLHe73;endothelial PAS domain-containing protein 1;EPAS-1;HIF;Hif like protein;HIF1 alpha-like factor;HIF1alpha-like factor;HIF-1-alpha-like factor;HIF-2;HIF2A;HIF2-alpha;HIF-2alpha;HIF-2-alpha;HIF-related factor;HL;HLF;HLF (HIF1alpha-like factor);HR;HRF;hypoxia inducible transcription factor 2alpha;hypoxia-inducible factor 2-alpha;mHLF;MO;MOP2. |
NCBI Gene Id | 13819 |
Protein Name | Endothelial PAS domain-containing protein 1 |
Description of Target | Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (PubMed:26245371). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity). |
Uniprot ID | P97481 |
Protein Accession # | NP_034267.3 |
Nucleotide Accession # | NM_010137.3 |
Protein Size (# AA) | Asp21~Cys336 |
Molecular Weight | 37kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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