DTX1 Recombinant Protein (OPCD02814)

Catalog No: OPCD02814

DTX1 Recombinant Protein (OPCD02814) using SDS-PAGE

DTX1 Recombinant Protein (OPCD02814) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Gly290-His535
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: DTX1
• Gene Full Name: deltex E3 ubiquitin ligase 1
• Alias Symbols: deltex 1, E3 ubiquitin ligase;deltex homolog 1;E3 ubiquitin-protein ligase DTX1;hDx-1;protein deltex-1;RING-type E3 ubiquitin transferase DTX1;RNF140.
• NCBI Gene Id: 1840
• Protein Name: E3 ubiquitin-protein ligase DTX1
• Description of Target: Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.
• Uniprot ID: Q86Y01
• Protein Accession #: NP_004407.2
• Nucleotide Accession #: NM_004416.2
• Protein Size (# AA): Gly290~His535
• Molecular Weight: 30.26kDa