DLD Recombinant Protein (OPCD02757)

Catalog No: OPCD02757

DLD Recombinant Protein (OPCD02757) using SDS-PAGE

DLD Recombinant Protein (OPCD02757) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Gly280-His487
  Subcellular Location: Mitochondrion matrix
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: DLD
• Gene Full Name: dihydrolipoamide dehydrogenase
• Alias Symbols: diaphorase;Dihydrolipoamide dehydrogenase;dihydrolipoyl dehydrogenase, mitochondrial;DLDD;DLDH;E3;E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex;epididymis secretory sperm binding protein;GCSL;glycine cleavage system L protein;glycine cleavage system protein L;LAD;lipoamide dehydrogenase;lipoamide reductase;lipoyl dehydrogenase;OGDC-E3;PHE3.
• NCBI Gene Id: 1738
• Protein Name: Dihydrolipoyl dehydrogenase, mitochondrial
• Description of Target: Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex) (PubMed:15712224, PubMed:16442803, PubMed:16770810, PubMed:17404228, PubMed:20160912, PubMed:20385101). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711). In monomeric form may have additional moonlighting function as serine protease (PubMed:17404228). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity).
• Uniprot ID: P09622
• Protein Accession #: NP_000099.2
• Nucleotide Accession #: NM_000108.4
• Protein Size (# AA): Gly280~His487
• Molecular Weight: 30kDa