- Gene Symbol:
- DLD
- NCBI Gene Id:
- 1738
- Official Gene Full Name:
- Dihydrolipoamide dehydrogenase
- Protein Name:
- Dihydrolipoyl dehydrogenase, mitochondrial
- Swissprot Id:
- B2R5X0
- Protein Accession #:
- NP_000099
- Nucleotide Accession #:
- NM_000108
- Alias Symbols:
- DLDH, E3, GCSL, LAD, PHE3
- Replacement Item:
- This antibody may replace item sc-119779 from Santa Cruz Biotechnology.
- Description of Target:
- DLD is the L protein of the mitochondrial glycine cleavage system. The L protein, also named dihydrolipoamide dehydrogenase, is also a component of the pyruvate dehydrogenase complex, the alpha-ketoglutarate dehydrogenase complex, and the branched-chain alpha-keto acide dehydrogenase complex. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency.This gene encodes the L protein of the mitochondrial glycine cleavage system. The L protein, also named dihydrolipoamide dehydrogenase, is also a component of the pyruvate dehydrogenase complex, the alpha-ketoglutarate dehydrogenase complex, and the branched-chain alpha-keto acide dehydrogenase complex. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
- Protein Size (# AA):
- 509
- Molecular Weight:
- 56kDa
- Host:
- Rabbit
- Clonality:
- Polyclonal
- Purification:
- Affinity Purified
- Application:
- IHC, WB
- Tissue Tool:
- Find tissues and cell lines supported by DNA array analysis to express DLD.
- RNA Seq:
- Find tissues and cell lines supported by RNA-seq analysis to express DLD.
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle region of human DLD
- Tested Species Reactivity:
- Human, Rat
- Predicted Homology Based on Immunogen Sequence:
- Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 86%; Rabbit: 100%; Rat: 93%; Yeast: 86%; Zebrafish: 93%
- Complete computational species homology data:
- Anti-DLD (ARP58455_P050)
- Peptide Sequence:
- Synthetic peptide located within the following region: AGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF
- Product Format:
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
- Reconstitution and Storage:
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
- Concentration:
- Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
- Protein Interactions:
- HUWE1; FUS; UBC; SUMO1; NEDD8; MDM2; ASB15; PEPD; LDHA; CKB; ASS1; CNDP2; TNFAIP8; DPP3; RPL23; FN1; ATF2; MRPL11; UBAP2; MRPL37; MRPL13; MRPL42; GGH; UQCRC2; UQCRC1; MRPL23; NONO; NDUFB5; NDUFA9; ETFB; DLAT; DBT; AK2; SIRT7; SLC2A4; PSMD4; OGDH; DLD; PDH
- Blocking Peptide:
- For anti-DLD (ARP58455_P050) antibody is Catalog # AAP58455 (Previous Catalog # AAPP34562)
- Datasheets/Manuals:
- Printable datasheet for anti-DLD (ARP58455_P050) antibody
- Sample Type Confirmation:
DLD is supported by BioGPS gene expression data to be expressed in HeLa, Jurkat, MCF7
- Target Reference:
- Wang,Y.C., (2008) J. Biomed. Sci. 15 (1), 37-46
Product Reviews
- Protocol:
- Tips Information:
See our General FAQ page.
Customer Reviews for DLD Antibody (ARP58455_P050) tested with Rat proximal kidney tubules purfied from cortex in Western blot
Product Protocols: DLD antibody tested with Human Jurkat Cells (ARP58455_P050)
Product Protocol: Rabbit Anti-DLD Antibody (ARP58455_P050) in Human Pineal Tissue using Immunohistochemistry
