COPB1 Antibody - middle region (ARP52371_P050)

Catalog No: ARP52371_P050

WB Suggested Anti-COPB1 Antibody Titration: 0.2-1 ug/ml
Positive Control: Human Liver

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human COPB1
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
• Peptide Sequence: Synthetic peptide located within the following region: QLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCS
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-COPB1 (ARP52371_P050) antibody is Catalog # AAP52371 (Previous Catalog # AAPP14315)
• Subunit: beta
• Reference: Goryachev,A.B. PLoS Comput. Biol. 2 (12), E172 (2006)

Target Info

• Gene Symbol: COPB1
• Gene Full Name: Coatomer protein complex, subunit beta 1
• Alias Symbols: COPB, BARMACS
• NCBI Gene Id: 1315
• Protein Name: Coatomer subunit beta
• Description of Target: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
• Uniprot ID: P53618
• Protein Accession #: NP_057535
• Nucleotide Accession #: NM_016451
• Protein Size (# AA): 953
• Molecular Weight: 107kDa
• Protein Interactions: SUMO2; NUDCD1; UBC; RNF2; EZH2; KLC1; DIAPH1; ARCN1; ACACA; COPG1; COPZ1; TLE3; FBXO6; UBD; KCNK3; KCNK9; NPM1; HDAC10; ERBB2IP; SNTA1; LZTS2; VPS18; NUB1; SERTAD1; FOXB1; IRAK3; TANK; ID1; HLA-DPB1; GRB2; XRCC6; FN1; CFTR; FMNL1; COPG2; COPE; COPB2; COPA