CD63 Antibody - FITC Conjugated (OACA00263)

Catalog No: OACA00263

Size:100ug

Product Info

• Predicted Species Reactivity: Mouse
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: FITC
• Application: WB
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Mouse CD63 antigen protein (103-203AA)
• Purification: Protein G Purified
• Purity: Caprylic Acid Ammonium Sulfate Precipitation purified
• Reference: [1] Molecular cloning of the murine homologue of CD63/ME491 and detection of its strong expression in the kidney and activated macrophages.Miyamoto M., Homma M., Hotta H.Biochim. Biophys. Acta 1217:312-316(1994)
  [2] The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamGenome Res. 14:2121-2127(2004)
  [3] Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.Nat. Biotechnol. 27:378-386(2009)
• Storage Buffer: Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Target Info

• Gene Symbol: Cd63
• Gene Full Name: CD63 antigen
• Alias Symbols: C75951;CD63 antigen;ME491;melanoma 1 antigen;Tsp;Tspan30.
• NCBI Gene Id: 12512
• Protein Name: CD63 antigen
• Description of Target: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
• Uniprot ID: P41731
• Protein Accession #: NP_001244318.1; NP_001244319.1; NP_001244320.1; NP_001244321.1; NP_001244329.1; NP_001244330.1
• Nucleotide Accession #: NM_001257; NM_001257389.1; NM_001257390.1; NM_001257391.1; NM_001257392.1; NM_001257400.1