REL Antibody (OAAB06846)

Catalog No: OAAB06846

Size:400ul

C-rel Antibody (Cat. #OAAB06846) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the C-rel antibody detected the C-rel protein (arrow).

Product Info

• Predicted Species Reactivity: Human
• Product Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
• Clonality: Monoclonal
• Clone: 318CT41.3.2
• Isotype: IgG2b,k
• Host: Mouse
• Application: WB
• Additional Information: Precautions: C-rel Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
  Function: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator
  Cellular Location: Nucleus (By similarity).
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This REL monoclonal antibody is generated from mouse immunized with REL recombinant protein.
• Predicted Homology Based on Immunogen Sequence: Human
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Application Info: WB: 1:120~1000

Target Info

• Gene Symbol: REL
• Alias Symbols: C-Rel, HIVEN86A
• NCBI Gene Id: 5966
• Protein Name: Proto-oncogene c-Rel
• Description of Target: Mouse Monoclonal Antibody (Mab)
• Uniprot ID: Q04864
• Protein Accession #: NP_002899.1
• Molecular Weight: 68520 Da