ARG2 Antibody (OACA06838)

Catalog No: OACA06838

Immunohistochemistry of paraffin-embedded human lung cancer at dilution 1:100

Immunohistochemistry of paraffin-embedded human prostate at dilution 1:100

All lanes: Arginase-2, mitochondrial antibody at 5ug/ml
Lane 1: mouse liver tissue
Lane 2: 293T whole cell lysate
Lane 3: mouse kidney tissue
Secondary
Goat polyclonal to rabbit at 1/1,0000 dilution
Predicted band size: 39kDa
Observed band size: 39kDa

All lanes: Arginase-2, mitochondrial antibody at 5ug/ml
Lane 1: mouse liver tissue
Lane 2: 293T whole cell lysate
Lane 3: mouse kidney tissue
Secondary
Goat polyclonal to rabbit at 1/1,0000 dilution
Predicted band size: 39kDa
Observed band size: 39kDa

Immunohistochemistry of paraffin-embedded human lung cancer at dilution 1:100

Immunohistochemistry of paraffin-embedded human prostate at dilution 1:100

Product Info

• Predicted Species Reactivity: Human|Mouse
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunohistochemistry|Immunoprecipitation|Western blot
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Human Arginase-2, mitochondrial protein (1-354AA)
• Purification: Affinity Purified
• Preservative: 0.02% sodium azide
• Formulation: PBS with, 50% glycerol, pH7.3.
• Reference: [1]Human arginase II: crystal structure and physiological role in male and female sexual arousal." Cama E., Colleluori D.M., Emig F.A., Shin H., Kim S.W., Kim N.N., Traish A.M., Ash D.E., Christianson D.W.Biochemistry 42:8445-8451(2003). [2]Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011). [3]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."The MGC Project TeamGenome Res. 14:2121-2127(2004)

Target Info

• Gene Symbol: ARG2
• Gene Full Name: arginase 2
• Alias Symbols: arginase II;arginase, type II;arginase-2, mitochondrial;kidney arginase;kidney-type arginase;L-arginine amidinohydrolase;L-arginine ureahydrolase;nonhepatic arginase;non-hepatic arginase;type II arginase.
• NCBI Gene Id: 384
• Protein Name: Arginase-2, mitochondrial
• Description of Target: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells (PubMed:27745970). May suppress inflammation-related signaling in asthmatic airway epithelium (PubMed:27214549). May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (By similarity). In fetal dendritic cells may play a role in promoting immune suppression and T cell TNF-alpha production during gestation (PubMed:28614294). Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PubMed:22928666). Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling (PubMed:25484082). Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity (PubMed:23832324). Since NOS is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase-2 plays a role in both male and female sexual arousal (PubMed:12859189).
• Uniprot ID: P78540
• Protein Accession #: NP_001163
• Nucleotide Accession #: NM_001172