Aviva Systems Biology office will be closed for Christmas and New Year Holiday - December 24-25, 2018 and January 1, 2019.
Please go here for more info.

Now Offering Over 102,157 Antibodies & 44,722 Antigens!

ARG2 antibody - C-terminal region (ARP54567_P050)

100 ul
$319.00
In Stock

Conjugation Options

ARP54567_P050-FITC Conjugated

ARP54567_P050-HRP Conjugated

ARP54567_P050-Biotin Conjugated

Gene Symbol:
ARG2
NCBI Gene Id:
384
Official Gene Full Name:
Arginase, type II
Protein Name:
Arginase-2, mitochondrial
Swissprot Id:
P78540
Protein Accession #:
NP_001163
Nucleotide Accession #:
NM_001172
Alias Symbols:
-
Replacement Item:
This antibody may replace item sc-114274 from Santa Cruz Biotechnology.
Description of Target:
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. ARG2 (type II isoform) is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism.Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Protein Size (# AA):
354
Molecular Weight:
39kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express ARG2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express ARG2.
Immunogen:
The immunogen is a synthetic peptide directed towards the C terminal region of human ARG2
Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 87%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%
Complete computational species homology data:
Anti-ARG2 (ARP54567_P050)
Peptide Sequence:
Synthetic peptide located within the following region: SALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPT
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
UBC; ARG1;
Blocking Peptide:
For anti-ARG2 (ARP54567_P050) antibody is Catalog # AAP54567 (Previous Catalog # AAPP31351)
Datasheets/Manuals:
Printable datasheet for anti-ARG2 (ARP54567_P050) antibody
Sample Type Confirmation:

ARG2 is supported by BioGPS gene expression data to be expressed in Jurkat

Target Reference:
Mumenthaler,S.M., (2008) Int. J. Oncol. 32 (2), 357-365
Publications:

Lukasova, M., Malaval, C., Gille, A., Kero, J. & Offermanns, S. Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells. J. Clin. Invest. 121, 1163-73 (2011). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat 21317532

Tell us what you think about this item!

Write A Review
    Please, wait...