ACVR1C Antibody (OAAF02550)

Catalog No: OAAF02550 (Formerly GWB-ASD769)

Size:100 ug

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ACTR-1C Antibody. The picture on the right is treated with the synthesized peptide.

Immunofluorescence analysis of COS7 cells, using ACTR-1C Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Paraffin
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human ACTR-1C.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: ACTR-1C antibody detects endogenous levels of total ACTR-1C protein.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: IHC: 1:50~1:100; IF: 1:00~1:500; ELISA: 1:20000
• Reference: Bondestam J., Cytogenet. Cell Genet. 95:157-162(2001).
  Roberts H.J., Biol. Reprod. 68:1719-1726(2003).
  Hillier L.W., Nature 434:724-731(2005).

Target Info

• Gene Symbol: ACVR1C
• Gene Full Name: activin A receptor type 1C
• Alias Symbols: activin A receptor, type IC;activin receptor type IC;activin receptor type-1C;activin receptor-like kinase 7;ACTR-IC;ACVRLK7;ALK7;ALK-7.
• NCBI Gene Id: 130399
• Protein Name: Activin receptor type-1C
• Description of Target: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
• Uniprot ID: Q8NER5
• Protein Accession #: NP_001104501.1
• Molecular Weight: 54 kDa