VRK1 Recombinant Protein (OPCD07934)

Catalog No: OPCD07934

VRK1 Recombinant Protein (OPCD07934) using SDS-PAGE

VRK1 Recombinant Protein (OPCD07934) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Gly46-Glu292
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: VRK1
• Gene Full Name: VRK serine/threonine kinase 1
• Alias Symbols: PCH1;PCH1A;serine/threonine-protein kinase VRK1;vaccinia related kinase 1;vaccinia virus B1R-related kinase 1;Vaccinia-related kinase 1.
• NCBI Gene Id: 7443
• Protein Name: Serine/threonine-protein kinase VRK1
• Description of Target: Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.
• Uniprot ID: Q99986
• Protein Accession #: NP_003375.1
• Nucleotide Accession #: NM_003384.2
• Protein Size (# AA): Gly46~Glu292
• Molecular Weight: 34kDa