U-18666A (OOMC00004)

Catalog No: OOMC00004

Product Info

• Product Format: Powder
• Additional Information: CAS: 3039-71-2
  Molecular Formula: C25H41NO2 - HCl
  Chemical Name: 3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride
  Primary Activity: Cholesterol transport inhibitor
  COVID-19 Rationale: Inhibits feline Coronavirus infection through cholesterol trafficking
• Reconstitution and Storage: Soluble in DMSO (up to 30 mg/ml) or in Water (up to 30 mg/ml). Store at room temperature.
• Purity: > 98%
• Reference: 1) Sexton et al (1983) Effects of 3.beta.-[2-(diethylamino)ethoxy]androst-5-en-17-one on the synthesis of cholesterol and ubiquinone in rat intestinal epithelial cell cultures. Biochemistry 22 5687 / 2) Liscum and Faust (1989) The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-b-[2-(diethylamino)ethoxy]androst-5-en-17-one. J.Biol.Chem. 264 11796 / 3) Cenedella, (2009) Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes: Lipids 44, 477

Target Info

• Molecular Weight: 387.61 - 36.46 g/mol