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Datasheets/Manuals | Printable datasheet for TNFSF18 Antibody (OACA06956) (OACA06956) |
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Predicted Species Reactivity | Human |
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Product Format | Liquid |
Clonality | Polyclonal |
Isotype | IgG |
Host | Rabbit |
Conjugation | Unconjugated |
Application | Enzyme-linked immunosorbent assay|Immunohistochemistry |
Reconstitution and Storage | -20°C or -80°C |
Immunogen | Recombinant Human Tumor necrosis factor ligand superfamily member 18 protein (72-199AA) |
Purification | Affinity Purified |
Preservative | 0.02% sodium azide |
Formulation | PBS with, 50% glycerol, pH7.3. |
Reference | [1]"Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: implications for function."Chattopadhyay K., Ramagopal U.A., Mukhopadhaya A., Malashkevich V.N., Dilorenzo T.P., Brenowitz M., Nathenson S.G., Almo S.C.Proc. Natl. Acad. Sci. U.S.A. 104:19452-19457(2007). [2]"Glucocorticoid-induced tumor necrosis factor receptor family-related ligand triggering upregulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 and promotes leukocyte adhesion."Lacal P.M., Petrillo M.G., Ruffini F., Muzi A., Bianchini R., Ronchetti S., Migliorati G., Riccardi C., Graziani G., Nocentini G.J. Pharmacol. Exp. Ther. 347:164-172(2013). [3]"Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells." Tuyaerts S., Van Meirvenne S., Bonehill A., Heirman C., Corthals J., Waldmann H., Breckpot K., Thielemans K., Aerts J.L.J. Leukoc. Biol. 82:93-105(2007). |
Gene Symbol | TNFSF18 |
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Gene Full Name | TNF superfamily member 18 |
Alias Symbols | activation-inducible TNF-related ligand;AITR ligand;AITRL;GITR ligand;GITRL;glucocorticoid-induced TNF-related ligand;glucocorticoid-induced TNFR-related protein ligand;hGITRL;TL6;TNLG2A;tumor necrosis factor (ligand) superfamily, member 18;tumor necrosis factor ligand 2A;tumor necrosis factor ligand superfamily member 18;tumor necrosis factor superfamily member 18. |
NCBI Gene Id | 8995 |
Protein Name | Tumor necrosis factor ligand superfamily member 18 |
Description of Target | Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity). |
Uniprot ID | Q9UNG2 |
Protein Accession # | NP_005083 |
Nucleotide Accession # | NM_005092 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "TNFSF18 Antibody (OACA06956)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "TNFSF18 Antibody (OACA06956)"?
This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".
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What buffer format is "TNFSF18 Antibody (OACA06956)" provided in?
This item is provided in "Liquid".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "TNFSF18 Antibody (OACA06956)"?
This target may also be called "activation-inducible TNF-related ligand;AITR ligand;AITRL;GITR ligand;GITRL;glucocorticoid-induced TNF-related ligand;glucocorticoid-induced TNFR-related protein ligand;hGITRL;TL6;TNLG2A;tumor necrosis factor (ligand) superfamily, member 18;tumor necrosis factor ligand 2A;tumor necrosis factor ligand superfamily member 18;tumor necrosis factor superfamily member 18." in publications.
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What is the shipping cost for "TNFSF18 Antibody (OACA06956)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "TNFSF18 Antibody (OACA06956)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "TNFSF18 Antibody (OACA06956)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "TNFSF18 Antibody (OACA06956)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "TNFSF18"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "TNFSF18"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "TNFSF18"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "TNFSF18"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "TNFSF18"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "TNFSF18"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.