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Datasheets/Manuals | Printable datasheet for SUV39H1 Antibody (OACA09483) (OACA09483) |
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Predicted Species Reactivity | Human |
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Product Format | Liquid |
Clonality | Polyclonal |
Isotype | IgG |
Host | Rabbit |
Conjugation | Unconjugated |
Application | Enzyme-linked immunosorbent assay|Immunohistochemistry |
Reconstitution and Storage | -20°C or -80°C |
Immunogen | Recombinant Human Histone-lysine N-methyltransferase SUV39H1 protein (179-412AA) |
Purification | Protein G Purified |
Preservative | 0.03% Proclin 300 |
Formulation | 50% Glycerol, 0.01M PBS, PH 7.4 |
Purity | >95% |
Gene Symbol | SUV39H1 |
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Gene Full Name | SUV39H1 histone lysine methyltransferase |
Alias Symbols | H3-K9-HMTase 1;histone H3-K9 methyltransferase 1;histone-lysine N-methyltransferase SUV39H1;histone-lysine N-methyltransferase, H3 lysine-9 specific 1;KMT1A;lysine N-methyltransferase 1A;MG44;position-effect variegation 3-9 homolog;Su(var)3-9 homolog 1;suppressor of variegation 3-9 homolog 1;SUV39H. |
NCBI Gene Id | 6839 |
Protein Name | Histone-lysine N-methyltransferase SUV39H1 |
Description of Target | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. |
Uniprot ID | O43463 |
Protein Accession # | NP_001269095 |
Nucleotide Accession # | NM_001282166 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "SUV39H1 Antibody (OACA09483)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "SUV39H1 Antibody (OACA09483)"?
This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".
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What buffer format is "SUV39H1 Antibody (OACA09483)" provided in?
This item is provided in "Liquid".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "SUV39H1 Antibody (OACA09483)"?
This target may also be called "H3-K9-HMTase 1;histone H3-K9 methyltransferase 1;histone-lysine N-methyltransferase SUV39H1;histone-lysine N-methyltransferase, H3 lysine-9 specific 1;KMT1A;lysine N-methyltransferase 1A;MG44;position-effect variegation 3-9 homolog;Su(var)3-9 homolog 1;suppressor of variegation 3-9 homolog 1;SUV39H." in publications.
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What is the shipping cost for "SUV39H1 Antibody (OACA09483)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "SUV39H1 Antibody (OACA09483)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "SUV39H1 Antibody (OACA09483)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "SUV39H1 Antibody (OACA09483)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "SUV39H1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "SUV39H1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "SUV39H1"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "SUV39H1"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "SUV39H1"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "SUV39H1"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.