Slc22A17 Antibody (OAPB00700)

Catalog No: OAPB00700

Size:100UG

Western blot analysis of Slc22A17 in SK-N-SH lysate with Slc22A17 antibody at 0.5 ug/ml in (A) the presence and (B) the absence of blocking peptide.

Immunofluorescence of Slc22A17 in rat kidney tissue cells with Slc22A17 antibody at 20 ug/mL.

Immunofluorescence of SLC22A17 in mouse kidney tissue with SLC22A17 antibody at 20 ug/ml.

Immunohistochemistry of SLC22A17 in mouse kidney tissue with SLC22A17 antibody at 2.5 ug/ml.

Product Info

• Predicted Species Reactivity: Bovine|Human|Mouse|Rat
• Product Format: Liquid. Slc22A17 Antibody is supplied in PBS containing 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: Slc22A17 antibody can be stored at 4C for three months. 20C for up to a year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Immunogen: Slc22A17 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of the human Slc22A17. The immunogen is located within the last 50 amino acids of Slc22A17.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human; Mouse; Rat
• Concentration: 1 mg/ml
• Blocking Peptide: For anti-Slc22A17 antibody is Catalog # OEPB02812
• Application Info: WB 0.5 ug/mL. Observed band: 61 kDA
  IF starting at 20 ug/ml
  IHC-P starting at 2.5ug/ml
  
• Other Applications Image 1 Data: Immunofluorescence of Slc22A17 in rat kidney tissue cells with Slc22A17 antibody at 20 ug/mL.
• Reference: Koepsell H and Endou H. The SLC22 drug transporter family. Pflugers Arch.2004; 447:666-76. ;Rizwan AN and Burckhardt G. Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles. Pharm. Res.2007; 24:450-70. ;Miharada K, Hiroyama T, Sudo K, et. al. Lipocalin 2-mediated growth suppression is evident in human erythroid and monocyte/macrophage lineage cells. J. Cell Physiol.2008; 215:526-37.;Devireddy LR, Gazin C, Zhu X, et al. A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Cell2005; 123:1293-305.

Target Info

• Gene Symbol: SLC22A17
• Gene Full Name: solute carrier family 22 member 17
• Alias Symbols: 24p3 receptor;24p3R;BOCT;BOIT;brain-type organic cation transporter;hBOIT;lipocalin-2 receptor;neutrophil gelatinase-associated lipocalin receptor;NGAL receptor;NGALR;NGALR2;NGALR3;potent brain type organic ion transporter;solute carrier family 22 (organic cation transporter), member 17;solute carrier family 22 member 17.
• NCBI Gene Id: 51310
• Protein Name: Solute carrier family 22 member 17
• Description of Target: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).
• Uniprot ID: Q8WUG5
• Molecular Weight: Predicted: 59 kDa Observed: 61 kDa