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PRUNE2 Antibody - C-terminal region (ARP85315_P050)

100 ul
$289.00
In Stock
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Gene Symbol:
PRUNE2
Official Gene Full Name:
prune homolog 2 (Drosophila)
NCBI Gene Id:
158471
Protein Name:
protein prune homolog 2
Swissprot Id:
Q8WUY3-5
Protein Accession #:
NP_001294976.1
Nucleotide Accession #:
NM_001308047.1
Alias Symbols:
BMCC1, BNIPXL, C9orf65, KIAA0367
Description of Target:
The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. In prostate cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. Prostate cancer antigen 3 regulates levels of this gene through formation of a double-stranded RNA that undergoes adenosine deaminase actin on RNA-dependent adenosine-to-inosine RNA editing. Alternative splicing results in multiple transcript variants.
Protein Size (# AA):
352
Molecular Weight:
38 kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express HNRPLL.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express PRUNE2.
Immunogen:
The immunogen is a synthetic peptide directed towards the C terminal region of human PRUNE2
Predicted Species Reactivity:
Human
Tested Species Reactivity:
Human
Peptide Sequence:
Synthetic peptide located within the following region: LNDTHPRRIKLTAPNINLSLDQSEGSILSDDNLDSPDEIDINVDELDTPD
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide:
For anti-PRUNE2 (ARP85315_P050) antibody is Catalog # AAP85315
Datasheets/Manuals:
Printable datasheet for anti-PRUNE2 (ARP85315_P050) antibody

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