PLN Antibody (Phospho-Ser232) (OASG00042)

Catalog No: OASG00042

Size:100 uL

Western Blot using 293T, Mouse Brain

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IHC, IF
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from human 14-3-3 Theta/Tau around the phosphorylation site of S232. Location: 170-250aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Phospho-Ser232
• Specificity: Phospho-14-3-3 Theta/Tau (S232) Polyclonal Antibody detects endogenous levels of 14-3-3 Theta/Tau protein only when phosphorylated at S232.
• Application Info: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000;

Target Info

• Gene Symbol: PLN, YWHAQ
• Gene Full Name: phospholamban
• Alias Symbols: PLB, CMD1P, CMH18
• NCBI Gene Id: 5350; 22630; 25577
• Description of Target: The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure.
• Uniprot ID: P27348, P68254, P68255
• Molecular Weight: 28 kDa