OPRD1 Antibody (OASG02227)

Catalog No: OASG02227

Size:100 uL

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat, Simian
• Product Format: Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IHC, ELISA
• Additional Information: Cellular Localization: Cell membrane
  Tissue Specificity: Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes.
• Reconstitution and Storage: Store at -20°C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived between 300-380 aa from human DOR-1 around the non-phosphorylation site of S363.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: N-glycosylated. Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4.
• Specificity: DOR-1 Polyclonal Antibody detects endogenous levels of DOR-1 protein.
• Application Info: WB: 1:500-1:2000
  IHC: 1:100-1:300
  ELISA: 1:20000
  Optimal dilutions should be determined by the end user.

Target Info

• Gene Symbol: OPRD1
• Gene Full Name: opioid receptor, delta 1
• Alias Symbols: DOP, DOR, DOR1, OPRD
• NCBI Gene Id: 4985
• Description of Target: G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.
• Uniprot ID: P41143, P32300, P33533
• Molecular Weight: 40/50 kDa