OAS1A Antibody (OACD06185)

Catalog No: OACD06185

Western Blot with Rat Recombinant 2'-5'-oligoadenylate synthase 1A

DAB staining on formalin fixed paraffin-embedded testis tissue

Western Blot with Rat Recombinant 2'-5'-oligoadenylate synthase 1A

DAB staining on formalin fixed paraffin-embedded testis tissue

Product Info

• Predicted Species Reactivity: Rat
• Product Format: Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
• Reconstitution and Storage: 2°C to 8°C|-20°C
• Immunogen: Range: Ala139 - Leu358
• Purification: Affinity Purified; Protein A Purified
• Concentration: 0.5 mg/ml
• Preservative: 0.02% NaN3
• Specificity: The antibody is a rabbit polyclonal antibody raised against OAS1. It has been selected for its ability to recognize OAS1 in immunohistochemical staining and western blotting.
• Formulation: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol
• Application Data: Western blotting: 1:50-400
  Immunocytochemistry in formalin fixed cells: 1:50-500
  Immunohistochemistry in formalin fixed frozen section: 1:50-500
  Immunohistochemistry in paraffin section: 1:10-100
  Enzyme-linked Immunosorbent Assay: 1:100-1:5,000
  Optimal working dilutions must be determined by end user.

Target Info

• Gene Symbol: Oas1a
• Gene Full Name: 2'-5' oligoadenylate synthetase 1A
• Alias Symbols: (2-5')oligo(A) synthase 1;(2-5')oligo(A) synthase 1A;(2-5')oligo(A) synthetase 1;2',5'-oligoadenylate synthetase 1, 40/46kDa;25 oligoadenylate synthetase;2'-5' oligoadenylate synthetase 1G;2-5A synthase 1;2-5A synthase 1A;2-5A synthetase 1;2'-5'-oligoadenylate synthase 1;2'-5'-oligoadenylate synthase 1A;2'-5'-oligoadenylate synthetase 1;Oas1;Oas1g.
• NCBI Gene Id: 192281
• Protein Name: 2'-5'-oligoadenylate synthase 1A
• Description of Target: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.
• Uniprot ID: Q05961
• Protein Accession #: NP_620268.1
• Nucleotide Accession #: NM_138913
• Molecular Weight: 42 kDa