NLRP4 Antibody (OABF01758)

Catalog No: OABF01758

Size:100UL

Formalin-fixed and paraffin embedded human colon carcinoma labeled with Rabbit Anti NALP4 Polyclonal Antibody, Unconjugated (OABF01758) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Formalin-fixed and paraffin embedded human lung carcinoma labeled with Rabbit Anti NALP4 Polyclonal Antibody, Unconjugated (OABF01758) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Formalin-fixed and paraffin embedded rat colitis labeled with Rabbit Anti NALP4 Polyclonal Antibody, Unconjugated (OABF01758) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Product Info

• Tested Species Reactivity: Human, Rat
• Predicted Species Reactivity: Horse|Human|Mouse|Porcine|Rat
• Product Format: Liquid Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin
• Additional Information: Subcellular location: Cytoplasm, Secreted, Extracellular matrix
• Reconstitution and Storage: -20°C
• Immunogen: KLH conjugated synthetic peptide derived from human NALP4
• Purification: Protein A Purified
• Concentration: 1 ug/ul
• Specificity: This antibody will detect multiple forms of NALP4, including the A, C and E Mouse variants.
• Application Info: ELISA: 1:500~1000
  IHC-P: 1:200~400
  IHC-F: 1:100~500
  Fluorescent (IHC-P): 1:50~200
  Fluorescent (IHC-F): 1:50~200
  Fluorescent-ICC: 1:50~200

Target Info

• Gene Symbol: NLRP4
• Gene Full Name: NLR family pyrin domain containing 4
• Alias Symbols: cancer/testis antigen 58;CLR19.5;CT58;NACHT, leucine rich repeat and PYD containing 4;NACHT, LRR and PYD domains-containing protein 4;NALP4;nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 4;PAAD and NACHT-containing protein 2;PAN2;PYPAF4;PYRIN and NACHT-containing protein 2;PYRIN-containing APAF1-like protein 4;ribonuclease inhibitor 2;RNH2.
• NCBI Gene Id: 147945
• Protein Name: NACHT, LRR and PYD domains-containing protein 4
• Description of Target: May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.
• Uniprot ID: Q96MN2