NE-100 (OOMC00067)

Catalog No: OOMC00067

Product Info

• Product Format: Powder
• Additional Information: CAS: 149409-57-4
  Molecular Formula: C23H33NO2 - HCl
  Chemical Name: 4-Methoxy-3-(2-phenylethoxy)-N,N,dipropylbenzeneethanamine hydrochloride
  Primary Activity: Ion channel: Sigma-1 antagonist (Selective)
  COVID-19 Rationale: Sigma 1 receptor antagonist (SARS-CoV-2 Nsp6 protein interacts with the Sigma receptor)
• Reconstitution and Storage: Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to 10 mg/ml). Store at -20C.
• Purity: > 98%
• Reference: 1) Okuyama et al. (1994), NE-100, a novel sigma receptor ligand: in vivo tests; Life Sci. 53 PL285 2) Chaki et al. (1994)), NE-100,a novel potent sigma ligand, preferentially binds to sigma 1 binding sites in guinea pig brain; Eur.J.Pharmacol. 251 R1 3) Ono et al. (2013), A sigma-1 receptor antaqonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells; Biochem.Biophys.Res.Commun. 434 904

Target Info

• Molecular Weight: 391.97 g/mol